KRN7000 research in Japan

Riken Institute research with Alpha-GalCer

Allogeneic DCG promote lung NK cell activation and antitumor effect after invariant NKT cell activation

Antitumor impact of interferon-γ producing CD1d-restricted NKT cells in murine malignant mesothelioma

Toll-like receptor agonists and alpha-galactosylceramide synergistically enhance the production of interferon-gamma in murine splenocytes

Activation of Invariant NKT Cells with Glycolipid Ligand α-Galactosylceramide Ameliorates Glucose-6-Phosphate Isomerase Peptide-Induced Arthritis

Altered expression and function of hepatic natural killer T cells in obese and diabetic KK-A(y) mice

The Activation of Natural Killer T Cells Ameliorates Post-Infarct Cardiac Remodeling and Failure in Mice

Antitumor immunity produced by the liver Kupffer cells, NK cells, NKT cells, and CD8 CD122 T cells

Activation of natural killer T cells by NK-4, a criptocyanine dye

A new experimental murine model for lipopolysaccharide-mediated lethal shock with lung injury

Nasal submucosal administration of antigen-presenting cells induces effective immunological responses in cancer immunotherapy

Role of natural killer T cells in the mouse colitis-associated colon cancer model

Th17 cells contribute to nontypeable Haemophilus influenzae-specific protective immunity induced by nasal vaccination with P6 outer membrane protein and α-galactosylceramide

SOCS1 regulates type I/type II NKT cell balance by regulating IFNgamma signaling

Induction of NKT cell-specific immune responses in cancer tissues after NKT cell-targeted adoptive immunotherapy

Endotoxin-induced lung injury in α-galactosylceramide-sensitized mice is caused by failure of interleukin-4 production in lung natural killer T cells

A phase I study of in vitro expanded natural killer T cells in patients with advanced and recurrent non-small cell lung cancer

α-Galactosylceramide activates antitumor immunity against liver tumor

Survival benefit of KRN7000 immune therapy in combination with TNP470 in hamster liver metastasis model of pancreatic cancer

Migration and immunological reaction after the administration of αGalCer-pulsed antigen-presenting cells into the submucosa of patients with head and neck cancer

Combining Carbon Ion Radiotherapy and Local Injection of α-Galactosylceramide-Pulsed Dendritic Cells Inhibits Lung Metastases in an In Vivo Murine Model

Adjuvant activity mediated by iNKT cells

A phase I-II study of alpha-galactosylceramide-pulsed IL-2/GM-CSF-cultured peripheral blood mononuclear cells in patients with advanced and recurrent non-small cell lung cancer

Role of interleukin-12 in determining differential kinetics of invariant natural killer T cells in response to differential burden of Listeria monocytogenes

Evaluation of the function of human invariant NKT cells from cancer patients using alpha-galactosylceramide-loaded murine dendritic cells

Nasal vaccination with P6 outer membrane protein and alpha-galactosylceramide induces nontypeable Haemophilus influenzae-specific protective immunity associated with NKT cell activation and dendritic cell expansion in nasopharynx

A set of genes associated with the interferon-γ response of lung cancer patients undergoing α-galactosylceramide-pulsed dendritic cell therapy

Human leukemic cells loaded with alpha-galactosylceramide (alpha-GalCer) activate murine NKT cells in situ

SOCS3 in T and NKT cells negatively regulates cytokine production and ameliorates ConA-induced hepatitis

Alpha-GalCer ameliorates listeriosis by accelerating infiltration of Gr-1+ cells into the liver

Interleukin-2 gene transfer potentiates the alpha-galactosylceramide-stimulated antitumor effect by the induction of TRAIL in NKT and NK cells in mouse models of subcutaneous and metastatic carcinoma

Combination therapy of in vitro-expanded natural killer T cells and alpha-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma

Antitumor activity of alpha-galactosylceramide, KRN7000, in mice with the melanoma B16 hepatic metastasis and immunohistological study of tumor infiltrating cells

Role of alpha-galactosylceramide-activated Valpha14 natural killer T cells in the regulation of allergic diseases

Alpha-galactosylceramide promotes killing of Listeria monocytogenes within the macrophage phagosome through invariant NKT-cell activation

Murine induced pluripotent stem cells can be derived from and differentiate
into natural killer T cells

NKT 細胞免疫系を標的にした頭頚部癌の

海洋天然物の新しい薬理活性 : 沖縄産海綿の生産するagelasphinを母化合物とするKRN7000の開発

A Phase I Study of Alpha-Galactosylceramide (KRN7000)–Pulsed Dendritic Cells in Patients with Advanced and Recurrent Non–Small Cell Lung Cancer

Activated liver dendritic cells generate strong acquired immunity in alpha-galactosylceramide treatment

Laboratory for Immune Regulation

Induction of Th1-biased cytokine production by Alpha-carba-GalCer, a neoglycolipid ligand for NKT cells

Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice

Antitumor Effect of Alpha-Galactosylceramide (KRN7000) on Spontaneous Hepatic Metastases Requires Endogenous Interleukin 12 in the Liver

Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders

Activation of Valpha24NKT cells in malignant pleural effusion in patients with lung cancer

The Effects of Natural Killer T Cells on Atherosclerosis

Neutralization of tumor necrosis factor abrogates hepatic failure induced by alpha-galactosylceramide without attenuating its antitumor effect in aged mice

Expansion of Valpha24(+)Vbeta11(+) NKT cells from cord blood mononuclear cells using IL-15, IL-7 and Flt3-L depends on monocytes

Dendritic cell maturation by CD11c- T cells and Valpha24+ natural killer T-cell activation by alpha-galactosylceramide

KRN7000, a novel immunomodulator, and its antitumor activities

Alpha-glycosylceramides enhance the antitumor cytotoxicity of hepatic lymphocytes obtained from cancer patients by activating CD3-CD56+ NK cells in vitro

Antitumor activity of alpha-galactosylceramide, KRN7000, in mice with EL-4 hepatic metastasis and its cytokine production

Cross-presentation of glycolipid from tumor cells loaded with alpha-galactosylceramide leads to potent and long-lived T cell mediated immunity via dendritic cells

Identification of canine natural CD3-positive T cells expressing an invariant T-cell receptor alpha chain

Intrahepatic delivery of alpha-galactosylceramide-pulsed dendritic cells suppresses liver tumor

Natural killer T cell-mediated antitumor immune responses and their clinical applications

Therapeutic effect of alpha-galactosylceramide-loaded dendritic cells genetically engineered to express SLC/CCL21 along with tumor antigen against peritoneally disseminated tumor cells

Cutting Edge: Inhibition of Experimental Tumor Metastasis by Dendritic Cells Pulsed with Alpha-Galactosylceramide

Mechanism of NKT cell activation by intranasal coadministration of alpha-galactosylceramide, which can induce cross-protection against influenza viruses

Potent Anti-tumor effects of Combination therapy using Interleukin-23 and .ALPHA.-galactosylceramide

Antitumor effect of whole body hyperthermia with alpha-galactosylceramide in a subcutaneous tumor model of colon cancer

Anti-tumor activity of KRN7000, an alpha-galactosylceramide and its action mechanism

Phase I study of alpha-galactosylceramide-pulsed antigen presenting cells administration to the nasal submucosa in unresectable or recurrent head and neck cancer

Multiple antigen-targeted immunotherapy with alpha-galactosylceramide-loaded and genetically engineered dendritic cells derived from embryonic stem cells

Activation of Valpha14+ Natural Killer T Cells by alpha-Galactosylceramide Results in Development of Th1 Response and Local Host Resistance in Mice Infected with Cryptococcus neoformans

alpha-Galactosylceramide, a ligand of natural killer T cells, inhibits allergic airway inflammation

In vitro induction of natural killer T cells from embryonic stem cells prepared using somatic cell nuclear transfer

Treatment with alpha-galactosylceramide attenuates the development of bleomycin-induced pulmonary fibrosis

Expansion of lung V alpha 14 NKT cells by administration of alpha-galactosylceramide-pulsed dendritic cells

Enhanced gamma interferon production through activation of Valpha14(+) natural killer T cells by alpha-galactosylceramide in interleukin-18-deficient mice with systemic cryptococcosis

Role of Valpha14+ NKT cells in the development of Hepatitis B virus-specific CTL: activation of Valpha14+ NKT cells promotes the breakage of CTL tolerance

Cytokine-dependent modification of IL-12p70 and IL-23 balance in dendritic cells by ligand activation of Valpha24 invariant NKT cells

Structure-activity relationship of alpha-galactosylceramides against B16-bearing mice

Treatment of hepatic metastasis of the colon26 adenocarcinoma with an alpha-galactosylceramide, KRN7000

Hyporesponsiveness to natural killer T-cell ligand alpha-galactosylceramide in cancer-bearing state mediated by CD11b+ Gr-1+ cells producing nitric oxide

Natural killer T cell ligand alpha-galactosylceramide inhibited lymph node metastasis of highly metastatic melanoma cells

Alpha-galactosylceramide-driven immunotherapy for allergy

Possibility of Immunotherapy Using V.ALPHA.24NKT Cells-Induction of Apoptosis in AML M4 Leukemia Cells by V.ALPHA.24NKT Cells Through TRAIL System

Expansion of alpha-galactosylceramide-stimulated Valpha24+ NKT cells cultured in the absence of animal materials

Application of natural killer T-cells to posttransplantation immunotherapy

Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Valpha14 NKT cells

alpha-Galactosylceramide (AGL-517) treatment protects mice from lethal irradiation

Effects of alpha-galactosylceramides on bone marrow cells in vitro and hematopoiesis in vivo

Enhancing effects of agelasphin-11 on natural killer cell activities of normal and tumor-bearing mice

Antitumor cytotoxicity mediated by ligand-activated human V alpha24 NKT cells

Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Valpha14 natural killer T cells

A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system

The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells

Potentiation of antitumor effect of NKT cell ligand, alpha-galactosylceramide by combination with IL-12 on lung metastasis of malignant melanoma cells

Immunization with dendritic cells loaded with alpha-galactosylceramide at priming phase, but not at boosting phase, enhances cytotoxic T lymphocyte activity against infection by intracellular bacteria

No inhibition of urinary bladder carcinogenesis in rats with intravesical instillation of alpha-galactosylceramide

Role of NKT cells and alpha-galactosyl ceramide

In vitro anti-tumour activity of alpha-galactosylceramide-stimulated human invariant Valpha24+NKT cells against melanoma

KRN7000 inhibit hepatic metastasis of pancreatic cancer

Development of KRN7000, derived from agelasphin produced by Okinawan sponge

Antitumor activities of combined treatment with a novel immunomodulator, (2S,3S,4R)-1-O-(alpha-D-Galactopyranosyl)-2-(N-Hexacosanoylamino)-1,3,4 - octadecanetriol (KRN7000), and radiotherapy in tumor-bearing mice

Valpha14 NK T cell-triggered IFN-gamma production by Gr-1+CD11b+ cells mediates early graft loss of syngeneic transplanted islets

Valpha24+ natural killer T-cell responses against T-acute lymphoblastic leukaemia cells: implications for immunotherapy

Association of ocular inflammation and innate immune response

A novel recognition motif of human NKT antigen

Activation of human Valpha24NKT cells by alpha-glycosylceramide in a CD1d-restricted and Valpha24TCR-mediated manner

Analysis of human V alpha 24+ CD4+ NKT cells activated by alpha-glycosylceramide-pulsed monocyte-derived dendritic cells

alpha-galactosylceramide induces early B-cell activation through IL-4 production by NKT cells

Involvement of decidual Valpha14 NKT cells in abortion

Positive selection of NKT cells by CD1(+), CD11c(+) non-lymphoid cells residing in the extrathymic organs

Requirement for IFN-gamma in IL-12 production induced by collaboration between v(alpha)14(+) NKT cells and antigen-presenting cells

Lethal endotoxic shock using alpha-galactosylceramide sensitization as a new experimental model of septic shock

Natural killer T cell-mediated immunotherapy for malignant diseases

Perspective of prevention and treatment for allergic diseases

DC therapy induces long-term NK reactivity to tumors via host DC

Antigen mRNA-transfected, allogeneic fibroblasts loaded with NKT-cell ligand confer antitumor immunity

Critical role of Valpha14+ natural killer T cells in the innate phase of host protection against Streptococcus pneumoniae infection

Localization of lymphocyte apoptosis in murine lymphoid tissues after stimulation of natural killer T cells with alpha-galactosylceramide

Essential role of bystander cytotoxic CD122+CD8+ T cells for the antitumor immunity induced in the liver of mice by alpha-galactosylceramide

Tumor-infiltrating effector cells of alpha-galactosylceramide-induced antitumor immunity in metastatic liver tumor

Translational research of NKT cell-based immunotherapy

Role of Valpha 14 NKT cells in the development of impaired liver regeneration in vivo

CD4+ CD25+ T cells responding to serologically defined autoantigens suppress antitumor immune responses

Immunoregulatory defects of V alpha 24V+ beta 11+ NKT cells in development of Wegener's granulomatosis and relapsing polychondritis

Impaired proliferative response of V alpha 24 NKT cells from cancer patients against alpha-galactosylceramide

Gene expression analysis in human monocytes, monocyte-derived dendritic cells, and alpha-galactosylceramide-pulsed monocyte-derived dendritic cells

Enhanced ability of peripheral invariant natural killer T cells to produce IL-13 in chronic hepatitis C virus infection

Mushroom acidic glycosphingolipid induction of cytokine secretion from murine T cells and proliferation of NK1.1 alpha/beta TCR-double positive cells in vitro

Monocyte chemoattractant protein-1-dependent increase of V alpha 14 NKT cells in lungs and their roles in Th1 response and host defense in cryptococcal infection

Activation of natural killer T cells by alpha-galactosylceramide mediates clearance of bacteria in murine urinary tract infection

Cytokine production and migration of in vitro-expanded NK1.1(-) invariant Valpha14 natural killer T (Valpha14i NKT) cells using alpha-galactosylceramide and IL-2

Clinical application of NKT cell system for lung cancer

Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide

Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways

TRAIL expression by activated human CD4(+)V alpha 24NKT cells induces in vitro and in vivo apoptosis of human acute myeloid leukemia cells

The critical role of Th1-dominant immunity in tumor immunology

The interface between innate and acquired immunity: glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes

The regulatory role of Valpha14 NKT cells in innate and acquired immune response

CD1d-mediated stimulation of natural killer T cells selectively activates hepatic natural killer cells to eliminate experimentally disseminated hepatoma cells in murine liver

Increased expansion of V alpha 24+ T cells derived from G-CSF-mobilized peripheral blood stem cells as compared to peripheral blood mononuclear cells following alpha-galactosylceramide stimulation

Current advances and expectations in tumor immunology

Killing activity of human umbilical cord blood-derived TCRValpha24(+) NKT cells against normal and malignant hematological cells in vitro: a comparative study with NK cells or OKT3 activated T lymphocytes or with adult peripheral blood NKT cells

Translational research in patients with lung cancer--clinical application of NKT cell immunotherapy

Enhancement of the synthetic ligand-mediated function of liver NK1.1Ag+ T cells in mice by interleukin-12 pretreatment

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New 7DW8-5 glycolipid


Now available 7DW8-5 glycolipid derivative of Alpha-GalCer for human and mice iNKT immunoresearch


Meet Funakoshi Company
at the following meetings:

NIH Research Festival
Bethesda, MD
September 13-14, 2018

San Diego, CA
December 8-12