KRN7000 applied to microbiology research:

Direct incorporation of the NKT-cell activator α-galactosylceramide into a recombinant Listeria monocytogenes improves breast cancer vaccine efficacy

The mechanism of splenic invariant NKT cell activation dictates localization in vivo

Viral Research

Protective role of α-galactosylceramide-stimulated natural killer T cells in genital tract infection with Chlamydia muridarum

Dysfunction of Natural Killer T Cells in Patients with Active Mycobacterium tuberculosis Infection

α-Galactosylceramide protects mice from lethal Coxsackievirus B3 infection and subsequent myocarditis

Unraveling Molecular Signatures of Immunostimulatory Adjuvants in the Female Genital Tract through Systems Biology

Endotoxin-induced lung injury in α-galactosylceramide-sensitized mice is caused by failure of interleukin-4 production in lung natural killer T cells

Invariant natural killer T cells: innate-like T cells with potent immunomodulatory activities

Natural killer T cells activated by a lipopeptidophosphoglycan from Entamoeba histolytica are critically important to control amebic liver abscess

Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders

Circulating Valpha24+Vbeta11+ NKT cell numbers and dendritic cell CD1d expression in hepatitis C virus infected patients

CD1d-dependent B-cell help by NK-like T cells leads to enhanced and sustained production of Bacillus anthracis lethal toxin-neutralizing antibodies

Multiple innate signaling pathways cooperate with CD40 to induce potent, CD70-dependent cellular immunity

Cd1d-dependent regulation of bacterial colonization in the intestine of mice

{alpha}-Galactosylceramide as a Therapeutic Agent for Pulmonary Mycobacterium tuberculosis Infection

The V{alpha}14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode

Nasal vaccination with P6 outer membrane protein and alpha-galactosylceramide induces nontypeable Haemophilus influenzae-specific protective immunity associated with NKT cell activation and dendritic cell expansion in nasopharynx

Prophylaxis of lipopolysaccharide-induced shock by alpha-galactosylceramide

Pivotal advance: alpha-galactosylceramide induces protection against lipopolysaccharide-induced shock

Alpha-galactosylceramide promotes killing of Listeria monocytogenes within the macrophage phagosome through invariant NKT-cell activation

Alpha-GalCer ameliorates listeriosis by accelerating infiltration of Gr-1+ cells into the liver

Incorporation of NKT cell-activating glycolipids enhances immunogenicity and vaccine efficacy of Mycobacterium bovis bacillus Calmette-Guerin

Activation of NKT cells protects mice from tuberculosis

alpha -galactosylceramide-activated Valpha 14 natural killer T cells mediate protection against murine malaria

Bacterial infection alters the kinetics and function of iNKT cell responses

Role of interleukin-12 in determining differential kinetics of invariant natural killer T cells in response to differential burden of Listeria monocytogenes

Immunization with dendritic cells loaded with alpha-galactosylceramide at priming phase, but not at boosting phase, enhances cytotoxic T lymphocyte activity against infection by intracellular bacteria

Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines

Invariant V alpha 14+ NKT cells participate in the early response to enteric Listeria monocytogenes infection

Lethal endotoxic shock using alpha-galactosylceramide sensitization as a new experimental model of septic shock

Critical role of Valpha14+ natural killer T cells in the innate phase of host protection against Streptococcus pneumoniae infection

Human NKT cells express granulysin and exhibit antimycobacterial activity

Monocyte chemoattractant protein-1-dependent increase of V alpha 14 NKT cells in lungs and their roles in Th1 response and host defense in cryptococcal infection

Acidification-dependent activation of CD1d-restricted natural killer T cells is intact in cystic fibrosis

Natural killer T cells are critical for dendritic cells to induce immunity in Chlamydial pneumonia

Rapid development of a gamma interferon-secreting glycolipid/CD1d-specific Valpha14+ NK1.1- T-cell subset after bacterial infection

NK T cell activation promotes Chlamydia trachomatis infection in vivo

Activation of natural killer T cells by alpha-galactosylceramide mediates clearance of bacteria in murine urinary tract infection

Pivotal advance: alpha-galactosylceramide induces protection against lipopolysaccharide-induced shock

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New 7DW8-5 glycolipid


Now available 7DW8-5 glycolipid derivative of Alpha-GalCer for human and mice iNKT immunoresearch


Meet Funakoshi Company
at the following meetings:

NIH Research Festival
Bethesda, MD
September 13-14, 2018

San Diego, CA
December 8-12